Despite the lower sensitivity of the ZNF genes relative to EDNRB and DCC, the 100% specificity of the individual ZNF genes suggests that ZNFs are promising candidates for HNSCC detection in a combination with ENDRB, DCC, or even with other candidates from Table 1 and S1 Fig, such as HHEX or FUZ/FLJ22688. Here, FUZ is linked to head and neck squamous cell carcinoma.