And in cervical carcinoma cells, over-expression of the mammalian CRB3 protein restores an epithelial-like morphology by organising a cortical actomyosin network through the regulation of the p114RhoGEF-RhoA-ROCK1/2 pathway via the FERM protein Ehm2 (Loie et al., 2015). Here, ROCK1 is linked to cervical carcinoma.