Liu et al investigated serum levels of IL33 and matrix metalloproteinase-28 (MMP-28) (n = 103) and found that serum levels of IL-33 were significantly lower (P< 0.01) and serum concentrations of MMP-28 were higher (P < 0.05) in acute myocardial infarction and unstable angina pectoris compared with stable angina and control groups [49]. The gene discussed is IL33; the disease is intermediate coronary syndrome.