The immune deficiency (IMD) triggered by Gram-negative bacteria, including the upper pattern recognition receptors i.e., PGRP-LC and PGRP-LE, and the downstream signaling molecules i.e., dFADD, Dredd, dTAK1, dIKK complex and Relish [2]. The gene discussed is PGLYRP1; the disease is Immunodeficiency.