Germ-line inactivation of UFBP1 caused anemia and embryonic lethality around E12.5 (Figs 1 and 2), whereas induced ablation of UFBP1 in adult mice impaired hematopoiesis, resulting in severe pancytopenia and animal death (Figs 3 and 4). The gene discussed is DDRGK1; the disease is anemia.