In agreement, CD56+high NK-cells accumulate within Th1-type chronic inflammatory lesions in a wide variety of pathological conditions such as rheumatoid arthritis [69], psoriasis [70], sarcoidosis [71], and allograft rejection [72] as well as in sites of intracellular bacterial infections [73], chronic viral infections [74], and tumors [75]. Here, NCAM1 is linked to rheumatoid arthritis.