Specifically for breast cancers, TRIM 24, 25 and 27 have been shown to be significant for breast cancer prognosis, such as facilitation of the ubiquitination of estrogen receptors or HER2 gene amplification (Hatakeyama 2011; Tsai et al. 2010; Chambon et al. 2011; Suzuki et al. 2005; Cao et al. 1996). The gene discussed is ESR1; the disease is breast carcinoma.