Several genes including GSTP1 (Glutathione S-transferase P1), RASSF1A (Ras association domain family 1A), and RARβ2 (Retinoic acid receptor β2) have been identified as methylated genes in breast cancer (Yamamoto et al. 2012; Arai et al. 2006; Miyake et al. 2012) but each of these markers is not always specific to breast cancer and several markers have been used in various combinations. This evidence concerns the gene RASSF1 and breast cancer.