However, since CIN in the index patient is limited to increase of somatic aneuploidy rates being significantly milder than in a cell population exhibiting alterations to the genes directly implicated in the aforementioned pathway (i.e. TP53, EP300, SP1 etc.)(Thompson et al. 2010; Roemer 2012; Heng et al. 2013; Pine and Liu 2014). Here, EP300 is linked to cervical squamous intraepithelial neoplasia.