Taking the intersection of common genes and DE genes into consideration, we obtained 19 genes (ALB, ASS1, GSTM3, MAD2L1, ALDH1B1, ALDH4A1, MAPK1, GSTZ1, GATM, FTCD, CCNA2, CENPF, GSTM4, ASNS, CCNB1, NAGS, ACY3, GSTA3, and ESPL1), which might play important roles in the ccRCC development. The gene discussed is ESPL1; the disease is nonpapillary renal cell carcinoma.