In conclusion, we successfully identified dysregulated genes (such as MAPK1 and CCNA2) and pathways (such as cell cycle, glutathione metabolism, and arginine and proline metabolism) of ccRCC in different stages, and these genes and pathways might be potential biological markers and processes for treatment and etiology mechanism in ccRCC. This evidence concerns the gene MAPK1 and nonpapillary renal cell carcinoma.