In particular, FGF-b, IL-8, VEGF, HGF, PDGFR, TGF-β, TNF-α, and OSM have been implicated in BM microenvironment alterations in patients with MPN [21, 22, 39–41, 68, 69]. The gene discussed is TGFB1; the disease is myeloproliferative neoplasm.