For example, Chen et al. [21] evaluated 7 SNPs (rs3818361 and rs6656401 in CR1; rs11136000, rs2279590, and rs9331888 in CLU; rs3851179 and rs541458 in PICALM) among 462 AD patients and 350 control subjects from southern Chinese population. This evidence concerns the gene CR1 and Alzheimer disease.