Endothelin-1 (ET-1) has been involved in many cancer-related processes, such as proliferation, angiogenesis, EMT and metastasis, many of these exerted through activation of multiple signaling cascades, including the Wnt/β-catenin pathway and its known targets such as cyclin D1, MMP2 and survivin [1, 20]. Here, EDN1 is linked to cancer.