Interestingly, Cav-1 and MnSOD had a moderate negative correlation (Pearson's R = −0.51, p < 0.001) in patients with invasive breast cancer (Figure 1G), and stratification of this cohort by low Cav-1 and high MnSOD expression in invasive ductal carcinoma indicated increased mortality (odds ratio, OR = 1.576, 95% CI 1.076 – 2.307, p < 0.05) and conferred risk of aggressive disease (OR = 2.099, 95% CI 1.321 – 3.333, p < 0.005), as shown in Table 1. This evidence concerns the gene CAV1 and invasive ductal breast carcinoma.