Moreover, the microophthalmia phenotype can be rescued by co-injection of WT Sox11 RNA.14 The fact that (1) Sox11 depletion leads to an eye phenotype14 similar to case 1 (our current study), (2) co-injection of Sox11 MO together with WT Sox11 RNA results in a rescue of the Sox11 MO-induced eye phenotype14 and (3) Sox11 MO injection does not lead to an increased death rate compared with control MO injection suggests that the microcephaly phenotype of Sox11 knockdown in X. laevis is not explained by non-specific toxic effects of MO injection. This evidence concerns the gene SOX11 and microcephaly.