APLN and obesity due to melanocortin 4 receptor deficiency: Indeed, the multivariate analysis of the association of apelin including sex, age, LVEF, T2-diabetes and ischemic HF with obesity gave odds ratio (OR) of 3.95 (95% CI, 1.31-11.94), p = 0.015 and 2.82 (95% CI, 1.23–6.47) per 100 pg/ml, p = 014 by using enter and stepwise computing method, respectively whereas association of apelin with ischemic heart failure status remained not significant, p = 0.566 (Table 3).