MYH9 and Macrothrombocytopenia: These autosomal dominant NMIIA mutations result in various MYH9-related disorders (MYH9-RD), including May-Hegglin anomaly, Epstein syndrome, Fechtner syndrome and Sebastian syndrome; the hallmark features of which are fewer, but giant, platelets (referred to clinically as macrothrombocytopenia) and leukocyte inclusions.