Of these three miRNAs, only miR-221 is predicted to regulatemurine ATF6 mRNA, and in βENaC-Tg mice, expression of miR-221 is increased in nativeairway tissues (tracheal and bronchial tissues) compared to wild-type mice.Together, the data implicate altered miRNA expression, in particular miR-221, incontrolling ATF6 levels in CF bronchial epithelium. Here, ATF6 is linked to cystic fibrosis.