(2008) found that a single exposure to HS (41.5°C, 15 min) is sufficient to increase the level of HSP72 protein in mouse skeletal muscle, and weekly treatment of HS (41.5°C, 15 min) for 16 weeks improved high-fat-diet-induced hyperinsulinemia and hyperglycemia in mice. This evidence concerns the gene HSPA1A and hyperinsulinism.