KLK3 and Familial prostate cancer: In univariate Cox proportional hazards analysis (Table 3), higher PSA (HR 1.509, 95 % CI 1.040–2.190, P = 0.03) and categorical BMI (≥25 kg/m2 vs. <23 kg/m2, HR 2.087, 95 % CI 1.033–4.215, P = 0.04) were both correlated with the BCR of prostate cancer.