FLG and Eczematoid dermatitis: We found strong correlation between the lead SNP rs12081541 (odds ratio (OR) 1.61; P=8.5 × 10−11), and a nearby loss-of-function mutation in the filaggrin gene (FLG R501X, D′=0.86, r2=0.18), a well-known risk factor for eczema and eczema-associated asthma8, 9.