However, the only significant locus identified in GWAS on allergic rhinitis, C11orf30/LRRC32 (ref. 57), is a known risk factor for eczema-associated asthma and hay fever13, suggesting that similar mechanisms may be involved in the atopic march from eczema to asthma and from eczema to allergic rhinitis. This evidence concerns the gene LRRC32 and asthma.