Finally, the chromosomal region around rs10445308 (OR 1.22; P=4.7 × 10−8), which is located in an intron of IKZF3 on chromosome 17 was found previously in studies on childhood asthma15, 16, 17, self-reported allergy18 and asthma plus hay fever (Supplementary Table 5)19. Here, IKZF3 is linked to asthma.