Indeed, in The AMD Gene Consortium paper, the effect sizes of ARMS2 rs10490924 and CFH rs10737680 for AMD were higher in Caucasian than in Asian patients, despite a lower prevalence of geographic atrophy, which is associated with a lower risk allele frequency, in Asians (Supplementary Figures 2A and 2B of The AMD Gene Consortium paper)25. This evidence concerns the gene ARMS2 and atrophic macular degeneration.