This has gained much attention recently because although matrix stabilization by TG2 is required for an effective tissue repair response, aberrant TG2 action has a central role in the pathogenesis of inflammatory diseases and autoimmunity, most noteably celiac disease (Aeschlimann and Thomazy, 2000; Iismaa et al., 2009). The gene discussed is TGM2; the disease is Autoimmunity.