ALB and Hyperbilirubinemia: Hyperbilirubinemia in Gunn rats is normally not associated with kernicterus, and they develop acute central nervous system dysfunction, and eventually irreversible brain damage, only when further challenged by administration of bilirubin-albumin displacers (e.g. sulphonamides) or of erythrocyte-lysing agents such as phenylhydrazine35.