Together with previous studies on the role of PTGIR, AATK and DPPA3 genes in cancer, their transcripts may represent candidate targets to be further examined for their specific role in SCC, and may extend the limited number of the mRNAs that are bona fide targets of PARN, including the above-mentioned cancer-related genes, as VEGF, IL-8, u-PA, c-jun, c-fos, TNF-alpha and p21. The gene discussed is JUN; the disease is cancer.