Correlated with PC aggressiveness through their ability to increase the self-renewal of putative PCSCs, promote EMT and stimulate AR target genes, members of the Wnt signaling family, namely Wnt-1, Wnt-3a and Wnt-11 [16], are substantially upregulated by SOX2 and their increased expression may lead to androgen deprivation therapy failure and PC recurrence [16]. This evidence concerns the gene AR and pachyonychia congenita.