The correlation between SOX2 expression by the primary tumor and the development of lymph node metastasis, together with the finding of SOX2-dependent upregulation of EMT transcription factors, neural CAMs, which mediate cell adhesion and migration [17–19] and members of the Wnt gene family, induced us to assess alterations in migration and invasion capabilities of SOX2-overexpressing PC3 and 22Rv1 cells. The gene discussed is SOX2; the disease is neoplasm.