Assessment of c-Myc, which has a prominent role in PC stem-like cells (PCSCs) / cancer initiating cells (CICs) maintenance and tumorigenicity [15], revealed a substantial upregulation, at the transcriptional (by 143%) and at the protein level, only in 22Rv1 cells (Figure 3A, 3B, 3C). This evidence concerns the gene MYC and cancer.