SOX2 overexpression by PC cell lines, either androgen-dependent or -independent, dramatically boosts a range of NED genes such as SYP, S100, CHGA and ENO2. We recently found that SNAI2 elicits SOX2 and NED gene expression in PC cell lines and that these genes frequently co-localized in the primary tumors [14]. Here, SYP is linked to pachyonychia congenita.