The leading role of SOX2 in this context is also corroborated by its ability to boost a network of pro-metastatic genes such as those coding for neural tissue associated molecules NrCAM, L1CAM and CHL1, which behave as physiological signaling transducers of axon guidance and neuronal migration, but also as aberrant drivers for tumor cell invasion and motility [17–19]. Here, L1CAM is linked to neoplasm.