SOX2 and metastatic malignant neoplasm in the lymph nodes: The multivariate analysis, adjusting for age, PSA levels and Gleason score, showed that the increase in SOX2 mRNA expression was significantly associated with the presence of lymph node metastasis (OR = 1.83 for each 1 unit increase in SOX2 mRNA expression; 95% CI: 1.43–2.35; Table 2).