The average tumor area of lymph nodes was 0.153 ± 0.054, 0.087 ± 0.054 and 0.033 ± 0.016 mm2 in mice with control cells, LN1–1 IGFBP3 sh4 and sh5 cells, respectively (Figure 5F). Here, IGFBP3 is linked to neoplasm.