IGFBP3 and metastatic malignant neoplasm in the lymph nodes: Importantly, 30 and 40% of the animals had lymph node metastasis after orthotopic injection of LN1–1 IGFBP3 sh4 (n = 9) and sh5 (n = 10) while 70% of the animals with lymph node metastasis after injection of LN1–1 cells expressing the vector control (Table 1).