Again, 37.5 and 42.9% of the experimental animals developed lymph node metastasis after orthotopic injection of OEC-M1 IGFBP3 (n = 8) and IGFBP3 GGG (n = 8) while 12.5% of the animals with lymph node metastasis after injection of OEC-M1 cells expressing the vector control (OEC-M1 PB) (Table 1). Here, IGFBP3 is linked to metastatic malignant neoplasm in the lymph nodes.