In contrast, S-Mepazine alone was able to suppress IL-6 and IL-10 expression in all ABC DLBCL cell lines, but the combination of both BTK and MALT1 inhibitors was severely augmenting the inhibitory effects on production of both interleukins in CD79 mutant ABC DLBCL cells (Figure 3E and 3F). Here, MALT1 is linked to diffuse large B-cell lymphoma.