In summary, the pattern of serum FGF21 concentrations in the present study did not differ significantly between patients with T2DM and normal controls, although fasting FGF21 in T2DM patients had the trend to be higher than healthy subjects.The temporal levels of FGF21 were significantly associated with FFAs, but not blood glucose, insulin or adiponectin. This evidence concerns the gene INS and type 2 diabetes mellitus.