AKT1 and pachyonychia congenita: In the 20 most highly enriched pathways from the GeneGo Database (Figure 4, right panel), we found that these outlier miRNAs involved pathways, including AKT signaling, the cell cycle (including the Skp1-cullin-F-box ubiquitin ligase (SCF) complex), and proteins related to the G1/S transition (including Ras and Rho proteins), were enriched in a series of cancers, especially in PC.