An enhanced Th2 response in keloid patients is also supported by: (1) an increased keloid incidence in high school students with allergies [51]; (2) a reduction in collagen synthesis in keloid and scleroderma fibroblasts by Tranilast, a drug developed to control allergies [52,53]; and (3) a correlation of excessive scar formation with IgE levels [54]. Here, IGHE is linked to allergic disease.