As described previously, two polymorphisms, +2109A/G (rs1861494) and +3810A/G, in intron 3 of the IFNγ gene associated with periportal fibrosis in a Sudanese population: the 2109G allele decreased IFNγ expression and correlated with severe fibrosis, whereas 3810A increased IFNγ expression and protected from fibrosis [106]. Here, IFNG is linked to fibrosis.