Somewhat surprisingly, three of the most well-studied of these polymorphisms, at −33, −589, and +3017, associate with asthma and/or elevated IgE in individuals of European descent but not in African populations (Table 3) [19,112–114]; the lack of association at −589T and +3017 in African populations may be due to their high frequency in these populations. The gene discussed is IGHE; the disease is asthma.