The genetic silencing of p53 in mice with conditional deletion of the BRCA2-interacting protein (BCCIP) gene also resulted in MB [41]; however the resulting tumor formation was predicated upon the loss of the BCCIP knockdown cassette, which restored BCCIP expression in the neuroectoderm, supporting a role for p53 in neuronal genomic stability. This evidence concerns the gene TP53 and neoplasm.