LIMK2 and cancer: To determine how LIMK inhibition affects cancer cell proliferation, we made use of the small molecular inhibitor N-{5-[2-(2,6-Dichloro-phenyl)-5-difluoromethyl-2H-pyrazol-3-yl]-thiazol-2-yl}-isobutyramide (compound 3 in [21]; hereafter referred to as LIMKi) that blocks both LIMK1 (7 nM IC50in vitro) and LIMK2 (8 nM IC50) activity.