Hematoxylin and eosin (H&E) stained tumor tissue sections displayed that CD44− C3A-iCSCs compared to CD44+ C3A-iCSCs exhibited well-differentiated tumor cells and contained more kinds of cell types, and CD44− C3A-iCSCs derived tumor cells morphology resembled H9 cells derived teratoma with three-germ morphology (Fig. 7C). The gene discussed is CD44; the disease is neoplasm.