ZC3H12D and oculopharyngeal muscular dystrophy: To determine whether the total DNA damage in terms of CNAs was differently distributed between the two histology groups (ND-OPMD versus D-OPMD/OSCC), the CNA data identified by the GISTIC analysis were processed as described in the Materials and Methods section, and the TFG, TBG, TFL and TBL were calculated for each histology group (Fig 3).