TM7SF2 and acute kidney injury: To investigate the effects of Tm7sf2 gene insufficiency in controlling renal injury in a model of experimental endotoxemia, we used Tm7sf2 WT and KO mice, injected intraperitoneally with 5mg/kg LPS, a relatively low and non-lethal dose that significantly decreases glomerular filtration rate and renal plasma flow, contributing to the induction of acute renal failure [16–17].