IL5 and eosinophilic granulomatosis with polyangiitis: There is also a potential role of cytokines like interleukin 5 and eotaxin-3, that are upregulated in EGPA and lead to eosinophil recruitment, and interleukin 25, produced in high amounts by eosinophils, which induces the Th2 responses and maintain the pathogenic process [28].