Also, in this study, noticeable elevations of blood glucose, insulin and HbA1c contents were detected in HFD control mice as compared with intact control, and with increases of pancreatic islet numbers, expansions, insulin- and glucagon-immunoreactive cells and insulin/glucagon cell ratios, suggesting the presence of type II diabetes in the histopathological observations. This evidence concerns the gene GCG and type 2 diabetes mellitus.