The temporal activation of CASP6 in the stroke penumbra corresponds with the progression of axonal degeneration, which is a major contributor to cell death.38, 39 Activated CASP6 has been observed in neuronal processes and cell bodies after stroke,40 with distinct patterns of mRNA expression following the induction of cerebral ischemia. The gene discussed is CASP6; the disease is Cerebral ischemia.