NF-200 has a critical role in maintaining neuronal shape,24, 25 and acting as a facilitator of axonal transport.26 To assess neuronal integrity after stroke and CASP6 or CASP8 inhibition, NF-200 immunostaining was examined in the peri-infarct region of the injured cerebral hemisphere (Figures 6a–l). Here, CASP8 is linked to Stroke.