UCHL1 and Alzheimer disease: UCH-L1 interacts with cytoskeletal and synaptic proteins, and thus may have an important role in axonal transport and synaptic function.7, 43, 44, 45, 46 Humans with mutations in UCH-L1 have been reported to have extensive white-matter abnormalities.5 Furthermore, UCH-L1 activity modulates LTP in hippocampus and is deficient in a mouse model of AD.4, 47 These data indicate that neuronal processes are more sensitive to 15dPGJ2-induced injury than the neuronal cell body and that the UCH-L1 C152A mutation protects neuronal processes from the toxic effects of CyPGs.