A recent study showed that CD133 can interact with p85 and activate the PI3K/Akt signal pathway, and this interaction results in the increased tumorigenic capacity of glioma stem cells.56 These results suggest that CD133 could have a role in modulating the expression of stemness genes in CSCs by interacting with several signal pathways; however, further investigation is required to understand the full potential of CD133 in CSC regulation. This evidence concerns the gene PROM1 and central nervous system cancer.