However, when NLC1-C was down-regulated in the cytoplasm, it accumulated in the nucleus of spermatogonia and primary spermatocytes, repressing miR-320a and miR-383 transcripts and leading to hyperactive proliferation of spermatogonia and primary spermatocytes by binding to Nucleolin, ultimately resulting in male infertility (Figure 7b). This evidence concerns the gene NUCLEOLIN and male infertility.