Along with resident macrophages (Kuppfer cells), the liver sinusoidal endothelial cells (LSEC) express GPBAR1, whose activation regulates the activity of endothelial nitric oxide (NO) synthase (eNOS) [3], suggesting a potential role for this receptor in the treatment of endothelial dysfunction in the setting of liver cirrhosis. This evidence concerns the gene GPBAR1 and endothelial dysfunction.