We recently reported that a new mouse model of AD, generated from a cross of a common AD mouse model (3xTgAD) with a mouse heterozygous for the BER enzyme DNA polymerase β (Polβ), had aggravated features of AD relative to the 3xTgAD mouse [15]: the reduction in Polβ in these 3xTg/Polβ mice induced neuronal dysfunction, cell death, and impaired memory and synaptic plasticity. This evidence concerns the gene POLB and Alzheimer disease.