Here, we used two different culture conditions to allow us to test different exposure times to study the effect of talazoparib on proliferating CLL cells, including the conditions that were previously used [12] and had enough material available to examine a sample which was confirmed as ATM non-functional (CLL 200, Figure 5 and supplementary figure S3) and another with confirmed p53 loss (CLL 199). This evidence concerns the gene TP53 and B-cell chronic lymphocytic leukemia.