Beside increased activity and expression of ST6GAL1, the increased expression of α2,6-sialylated sugar chains (see Sia6LacNAc structure in Figure 3) has also been observed in colon cancer specimens, which were detected using SNA (Sambucus nigra agglutinin - a specific lectin that binds preferentially to sialic acid attached to a terminal galactose) [87]. Here, ST6GAL1 is linked to colonic neoplasm.