An elegant study using DLD-1/Δα cells, a subclone of the human colon carcinoma DLD-1 cell line that lack α-catenin (an actin-binding protein at the AJs) expression, revealed that restoration of the α-catenin gene result in both a rescue of the cortical actin staining pattern (typical of epithelial cells) and a significant increase in MGAT3 activity, suggesting that MGAT3 expression is tightly regulated by cell-cell adhesion via the E-cadherin-catenin complex [57]. The gene discussed is CDH1; the disease is colon carcinoma.