In cancer cells, NFIL3 physically associates with Histone deacetylase 2 (HDAC2) to repress the TRAIL (Tumor Necrosis Factor Ligand Superfamily, Member 10), FAS (TNF receptor superfamily member 6) and GADD45a (Growth Arrest and DNA-damage-inducible, alpha) genes2. This evidence concerns the gene HDAC2 and cancer.