Interestingly, the M1L, R19Q, R21C, and T24 mutant forms of FOXO1 (found in DLBCL) failed to be phosphorylated on T24, failed to interact with 14-3-3 and were retained in the nucleus to presumably drive gene expression, suggesting a pro-oncogenic role for nuclear FOXO1 in this setting74. The gene discussed is FOXO1; the disease is diffuse large B-cell lymphoma.