Neutrophils, a key initiator of classical autoinflammation, can go beyond their typical autoinflammatory roles to link the innate immune system with adaptive responses in BD by generating chemotactic signals (e.g., IL8/TNFα), expressing costimulatory molecules and releasing proinflammatory cytokines (e.g., IFNγ) [57]. Here, TNF is linked to Behcet disease.