A BD specific peptide, p336–351, present within the hHSP60 initiated uveitis in rats and following tolerization, both animal model and human trial showed decreased expression of CCR5, CXCR3, CCR7, and costimulatory molecules including CD28 and CD40 by Th1 cells with little or no IFNγ and TNFα production and thereby preventing the initiation of BD uveitis. This evidence concerns the gene TNF and Behcet disease.