Zanotti et al. [14] detected serum HE4 levels in 193 patients with endometrial carcinoma and in 125 healthy controls, and the results showed that a preoperative increase in HE4 is an independent prognostic factor for decreased overall survival, disease-free survival, and tumor progression-free survival in patients with endometrial cancer. This evidence concerns the gene WFDC2 and endometrial carcinoma.