As an example of this, EXs purified from human kidney adenocarcinoma ACHN cells inhibited proliferation and induced apoptosis of Jurkat-immortalized T-cells while reducing in vitro interleukin-2 (IL-2), IL-6, IL-10 and interferon-γ production (Yang et al., 2013). The gene discussed is IL2; the disease is renal cell adenocarcinoma.