The same paper also demonstrates that miR-29c provides indicators of renal function and the histological degree of fibrosis, making it the most prominent candidate for a biomarker of CKD, while (Lv et al., 2014) showed that the exosomal mRNA level of CD2-associated protein (CD2AP) was down-regulated in CKD patients, and even more so in patients with a more severe disease. The gene discussed is CD2AP; the disease is chronic kidney disease.