Increased serum levels of LMW-HA, created by blocking the HA receptor for endocytosis (HARE/Stab2) found in sinusoidal endothelium in the liver, bone marrow, and lymph nodes, prevented B16F10 melanoma cells from binding to endothelial cells and producing lung foci in tail-vein injected mice (105). Here, STAB2 is linked to melanoma.